Congratulations to PD-MitoQUANT PI Prof Ronal Melki of the Centre National de la Recherche Scientifique (CNRS) and co-authors M Landureau, V Redeker, T Bellande, and S Eyquem. Their open-access paper, The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs was accepted for publication in the Journal of Biological Chemistry on April 28th, 2021. DOI: https://doi.org/10.1016/j.jbc.2021.100737.

This work provides specific fingerprints for distinct fibrillar alpha-synuclein assemblies that yield distinct synucleinopathies.

Read the lay summary of this important paper here.