PD-MitoQUANT PI Prof. Dr Ronald Melki, CNRS, Fontenay-aux-Roses, France is the co-organizer of the Protein phase transitions in aging and age-related diseases: from atomic resolution to cellular solutions conference which will take place in Roscoff, Brittany, France from October 17th through the 21st, 2022. The deadline for applications is June 13th; click here for application guidelines. Invited speakers include PI Dr Olga Corti, ICM, who will speak about Mitochondrial quality control in Parkinson’s disease and Ronald Melki, CNRS: Fibril polymorphisms and propagation
About this meeting:
Cells and organisms maintain protein homeostasis in several cooperating ways, which include protein folding, degradation, and sequestration. During aging, the ability to maintain protein homeostasis declines, which leads to the accumulation of aggregation-prone proteins. These aggregation-prone proteins can accelerate aging and cause age-related diseases like Parkinson’s disease, tauopathies, Alzheimer’s, and Amyotrophic Lateral Sclerosis. How they do so is still not fully understood. Understanding the underlying mechanisms will be important for the development of therapeutic strategies. Recent groundbreaking discoveries have revealed new aspects of protein homeostatic and pathological mechanisms. These include the phenomena of protein phase transitions in membrane-less organelles and the existence of amyloid polymorphisms that are associated with protein toxicity. These phenomena are shared by a range of stress and age-related conditions. This Jacques Monod meeting will highlight these phenomena, including the biological mechanisms and structural features involved. New findings will be presented by scientists that pioneered the research in these areas. Regulation of both physiological and disease-related transitions will be addressed as well as perspectives on biomedical applications. New findings will be presented by scientists that pioneered the research in these areas. Regulation of both physiological and disease-related transitions will be addressed as well as perspectives on biomedical applications. New findings will be presented by scientists that pioneered the research in these areas. Regulation of both physiological and disease-related transitions will be addressed as well as perspectives on biomedical applications.
The meeting will bring together leading experts in the fields of structural biology, cell biology, physiology and medical biology. It aims to foster exchange of knowledge across these fields and to stimulate interdisciplinary collaboration to further advance the filed.