Congratulations to Maya Bendifallah, Virginie Redeker, Elodie Monsellier, Luc Bousset*, Tracy Bellande, and Ronald Melki* for the publication of their recent study entitled: Interaction of the chaperones alpha B-crystallin and CHIP with fibrillar alpha-synuclein: Effects on internalization by cells and identification of interacting interfaces. The paper appeared in the journal Biochemical and Biophysical Research Communications on May 17, 2020. This is the sixth PD-MitoQUANT-referenced paper. Find the entire list, read the abstracts and download the pdfs of these open-access studies [...]
The current situation regarding the Coronavirus disease (COVID-19) is significantly impacting the research community, including the PD-MitoQUANT international consortium. We anticipate that the precise nature of these impacts will evolve over the coming weeks and months. Our institutions' priority is the safety and wellbeing of all people, including our own research teams. The consortium is working together to come up with solutions to reduce delays to the project as a result of the practical measures taken to contain the virus.
With headquarters in Denmark, Lundbeck is a global pharmaceutical company highly committed to improving the quality of life of people living with brain diseases. For this purpose, Lundbeck is engaged in research, drug discovery development, manufacturing, marketing and sale of pharmaceuticals across the world. The company’s products are targeted at disease areas within psychiatry and neurology. Within PD-MitoQUANT, Lundbeck: is scientific co-leader as part of the PD-MitoQUANT Executive Team, evaluates a range of α-synuclein (α-αSyn) fibril species to select the most [...]
The public, including patients, can and should be involved in all aspects of research, including study design, communication, and ethics. Patients bring unique knowledge and skills to projects, which can improve the quality of research. The Innovative Medicines Initiative encourages public and patient involvement (PPI) in all of its projects. PD-MitoQUANT is fortunate to have two people with Parkinson’s involved in the project through our patient advocacy partner Parkinson’s UK. Here, we meet Paula Scurfield. Paula was diagnosed with Parkinson’s [...]
PD-MitoQUANT is fortunate to have two people with Parkinson’s, Richard Campbell and Paula Scurfield, involved in the project through our patient advocacy partner Parkinson’s UK (www.parkinsons.org.uk). Recently, Richard wrote a blog entitled “Getting involved in an international research project on Parkinson’s”. "Paula Scurfield and I are part of the Parkinson’s UK Research Support Network and have joined the project as patient and public representatives. Our role is to advise on how information about the project is communicated, and how findings are shared [...]
Congratulations to our partners at the Centre National de la Recherche Scientifique (CNRS) for their March 17, 2020, open-access paper published in Scientific Reports. The paper entitled "The expression level of alpha-synuclein in different neuronal populations is the primary determinant of its prion-like seeding" was authored by Josquin Courte, Luc Bousset, Ysander Von Boxberg, Catherine Villard, Ronald Melki & Jean-Michel Peyrin. Find the entire list of PD-MitoQUANT acknowledged papers here: https://www.pdmitoquant.eu/publications/
The 'Parkison's Research in Ireland' event planned for Wednesday, 1st April 2020 has been cancelled and will be re-scheduled for a later date.
The open-access study titled: Differential Membrane Binding and Seeding of Distinct α-Synuclein Fibrillar Polymorphs published by the team consisting of AN Shrivastava, Luc Bousset, M Renner, V Redeker, J Savistchenko, A Triller and Ronald Melki was recently published in the Biophysical Journal on the 27th of January 2020. Congratulations to the whole team! See the growing list of PD-MitoQUANT-acknowledged publications here: https://www.pdmitoquant.eu/publications
Happy New Year to all who are following the progress of PD-MitoQUANT. We are pleased to provide you with our latest project update. Please find our January 2020 newsletter for download here.
Congratulations to all authors involved in the latest PD-MitoQUANT-acknowledged publication: Nolwen L. Rey, Luc Bousset, Sonia George, Zachary Madaj, Lindsay Meyerdirk, Emily Schulz, Jennifer A. Steiner, Ronald Melki and Patrik Brundin. PD-MitoQUANT PIs Luc Bousset and Ronald Melki are researchers at the Centre National de la Recherche Scientifique (CNRS). The open access paper entitled: α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb appears in Acta Neuropathologica Communications (2019) 7:221. The study was [...]