The annual Molecular and Computational Biology Symposium took place at the Conway Institute of Biomolecular and Biomedical Research in University College, Dublin (UCD) on the 21st and 22nd of November 2019. The symposium which involved international keynote speakers was organised by Ph.D. students from Systems Biology Ireland, the School of Veterinary Science, the School of Computer Science and the Conway Institute for Biomolecular and Biomedical research. Sandeep Chenna, RCSI At it, RCSI Research Assistant Sandeep Chenna presented PD-MitoQUANT- [...]
PD-MitoQUANT researcher Dr. Orla Watters from the Royal College of Surgeons in Ireland presented a poster entitled: The effects of local energetic stress on mitochondrial transport in primary cortical axons at the Society for Neuroscience (SfN) 2019 conference in Chicago, IL, USA. Other authors contributing to the study poster were N. M. C. Connolly, H-G. König, H. Düssmann, and J. H. M. Prehn. The poster was presented on Saturday, the 19th of October at 13:00-17:00 poster session. Download the pdf [...]
Researchers looking for a brief snapshot of PD-MitoQUANT to insert into their presentations need to look no further! With distinct audiences in mind, we have created two brief slide decks to describe the work undertaken in PD-MitoQUANT and to acknowledge all partners in and funders of the project. Download the slides for scientific presentations here. Download the slides for a general public audience here.
PD-MitoQUANT is one of twelve research projects launched by the Innovative Medicines Initiative, Europe's biggest public and private collaboration in life sciences, which aim to better understand and develop treatments for neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. PD-MitoQUANT has joined forces with these research projects on the Neuronet platform to aid progress and expedite the delivery of novel treatments. A memorandum of understanding was jointly signed by Coordinator Prof Jochen Prehn, RCSI and Carlos Díaz, Coordinator of [...]
In October 2020, PD-MitoQUANT PI Dr Ronald Melki, CNRS is co-chairing the Jacques Monod conference which is themed: Protein phase transitions in ageing and age-related diseases: from atomic resolution to cellular solutions. Several PD-MitoQUANT PIs will present here. Where: Roscoff (Bretagne), France When: October 12-16, 2020 REGISTRATION REQUEST and ABSTRACT SUBMISSION DEADLINE: June 12, 2020 The conference- Cells and organisms maintain protein homeostasis in several cooperating ways, which include protein folding, degradation, and sequestration. During aging, the capacity to maintain protein [...]
PD-MitoQUANT PI Dr Ronald Melki of the Centre National de la Recherche Scientifique, CNRS was an invited speaker at the International Symposium on Neurodegenerative Diseases organized by the University of Texas Southwestern O’Donnell Brain Institute in Dallas, Texas and the Texas Alzheimer’s Research and Care Consortium. The meeting took place on October 24 and 25, 2019 at the T. Boone Pickens Biomedical Building, NG3.11. Ronald's talk entitled "Prion-like propagation of alpha-synuclein and Tau assemblies in synucleinopathies and tauopathies" was [...]
Institut du Cerveau et de la Moelle Epinière (ICM) PI Dr Olga Corti presented her work and acknowledged PD-MitoQUANT at two recent conferences. The first conference presentation was on September 3, 2019, at the 23rd Biennial ESN meeting in Milan. Olga's talk was titled: “From dysfunction of PINK1/Parkin-mediated mitochondrial quality control to Parkinson’s disease”. See the entire programme here. In Coimbra, Olga presented at the 8th Workshop of the European Calcium Society. Her presentation was “Mechanisms underlying regulation of mitochondrial [...]
PD-MitoQUANT partners at Institut du Cerveau et de la Moelle Epinière recently co-authored a study entitled "The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells." in Scientific Reports on August 14, 2019. This work was undertaken by M. Jacoupy, E. Hamon-Keromen, A.Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury laCour, M. J. Millan, J.A. Boutin, J.W. Harper, A. Brice, D.Guedin, C.A.Gautier and O. Corti. Congratulations to the team! "Most of over a [...]
On September 3, 2019, PD-MitoQUANT PI Dr Ronald Melki, Team Leader of the Protein misfolding and aggregation in neurodegenerative diseases group at CNRS delivered the keynote lecture at the 4-day SYNUCLEIN meeting. Following on from the keynote talk, Ronald chaired a round table discussion titled: Alpha-synuclein aggregation: how does it happen? Participants at the table included Daniel Otzen, Ronald Melki and Hilal Lashuel. The 2019 meeting which took place in Ofir on the outskirts of Porto in Portugal was themed [...]
A review was recently published in the Journal of Neurochemistry which acknowledged PD-MitoQUANT research funding. "α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities" authored by a team consisting of Parvez Alam, Luc Bousset, Ronald Melki and Daniel E. Otzen appeared in the 29 June 2019 issue. Ronald and Luc are PD-MitoQUANT PIs from the Centre National de la Recherche Scientifique, the CNRS in France. Download the open access paper here. Congratulations to all!