News – PD-MitoQUANT

Publication news from DZNE

pdmq_admin2023-06-12T16:50:40+01:00September 9th, 2022|News, Partner in the Spotlight, Publication|

Our PI Prof. Donato A. DiMonte of the German Center for Neurodegenerative Diseases (DZNE) and co-authors Michael Helwig, Ayse Ulusoy, Angela Rollar, Sinead A. O’Sullivan, Shirley S. L. Lee, Helia Aboutalebi, Rita Pinto-Costa, Benjamin Jevans, and Michael Klinkenberg announce the publication of "Neuronal hyperactivity–induced oxidant stress promotes in vivo alpha-synuclein brain spreading" in Volume 8, No. 35 of Science Advances on August 31st, 2022. DOI: 10.1126/sciadv.abn0356

Check out our final newsletter!

pdmq_admin2022-08-31T16:11:54+01:00August 31st, 2022|News, Partner in the Spotlight|

It's hard to believe we reached the end of the project in July 2022. Our final newsletter is now out, with an update on our most recent publications and dissemination activities. You can also read about our last consortium meeting in Copenhagen, including the parting thoughts of our public patient involvement (PPI) volunteers.

Review article from DZNE published in The Lancet

pdmq_admin2022-08-25T09:19:43+01:00August 25th, 2022|News, Partner in the Spotlight, Publication|

"AIFM1 beyond cell death: An overview of this OXPHOSinducing factor in mitochondrial diseases," an open-access review article prepared by Lena Wischhof, Enzo Scifo, Dan Ehninger and our PD-MitoQUANT PI Daniele Bano was published in eBioMedicine, part of The Lancet Discovery Science on August 18th, 2022. The research team is based at the German Center for Neurodegenerative Diseases (DZNE), in Bonn, Germany. DOI: https://doi.org/10.1016/j.ebiom.2022.104231 Summary: Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this [...]

New PD-MitoQUANT research published in IEEE conference proceedings

pdmq_admin2022-07-14T08:46:37+01:00July 8th, 2022|News, Partner in the Spotlight, Publication|

Congratulations to PD-MitoQUANT researchers Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna of the RCSI! Their paper "Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism" was published open access on July 8th, 2022 as part of the 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) proceedings. DOI: 10.1109/BIBM52615.2021.9669351 Download the PDF here.

Parting Thoughts from our Public Patient Involvement Volunteers

pdmq_admin2022-08-25T10:07:24+01:00July 6th, 2022|News|

We’ve been privileged to have two people with Parkinson’s join the consortium. At our final project meeting in Copenhagen, Richard and Paula gave an inspirational farewell message, highlighting why continuing Parkinson’s research is so important. You can see their final presentation here. Richard Campbell I was very impressed by the co-operation of the different research laboratories, academic institutions, pharmaceutical companies and charities in the PD-MitoQUANT consortium. The leadership and management of the project [...]

Final Project Meeting in Copenhagen

pdmq_admin2022-07-06T09:05:03+01:00July 6th, 2022|News|

Time has certainly flown! With the project formally ending in July 2022, project partners gathered in Copenhagen from 28 - 29 June for a final meeting, hosted by Lundbeck. Recent target validation results were the main focus of the meeting. As always, lots has been done but there is still much more to do! Young researchers also had a chance to showcase their results in a poster session with Noemi [...]

Joint PD-MitoQUANT publication in Cell Physiology

pdmq_admin2022-06-07T16:56:16+01:00June 7th, 2022|News, Publication|

Congratulations to the PD-MitoQUANT research team of Sandeep Chenna (Royal College of Surgeons in Ireland, RCSI), Werner J.H. Koopman (Radboud University Medical Center), Jochen H.M. Prehn (RCSI), and Niamh M.C. Connolly (RCSI) for the May 25th, 2022 publication of their review titled "Mechanisms and mathematical modelling of ROS production by the mitochondrial electron transport chain" in the journal Cell Physiology. DOI: https://doi.org/10.1152/ajpcell.00455.2021

PD-MitoQUANT research presented at Dutch Translational Metabolism Conference

pdmq_admin2022-05-30T13:16:29+01:00May 30th, 2022|News, Partner in the Spotlight|

Post-doc Dr Shruti Desai of the Radboud University Nijmegen Medical Centre (RUMC) and Sandeep Chenna of the RCSI will present PD-MitoQUANT research at the 2022 Dutch Translational Metabolism Conference, which will be held in Wageningen on June 13th and 14th (https://www.translationalmetabolism.nl/). Shruti's poster is titled: PD-MitoQUANT: Quantification of Mitochondrial Morphofunction in hiPSC- derived Cortical Neurons. Sandeep's is titled: Systems modelling of mitochondrial bioenergetics and genome scale metabolic modelling to explore molecular defects contributing to pathogenesis in Parkinson’s. The aim of the [...]

PD-MitoQUANT team publication in Cells journal

pdmq_admin2022-05-16T11:42:13+01:00May 16th, 2022|News, Publication|

Congratulations to the PD-MitoQUANT team of Aurore Tourville, David Akbar, Olga Corti, Jochen H. M. Prehn, Ronald Melki, Stéphane Hunot and Patrick P. Michel from ICM, CNRS and RCSI for the publication of their open-access study titled: Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons in Cells on May 13th, 2022. Citation: Tourville, A.; Akbar, D.; Corti, O.; Prehn, J.H.M.; Melki, R.; Hunot, S.; Michel, P.P. Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds [...]

Neuronet releases Decision Tool for engagement with Regulatory and Health Technology Assessment bodies

pdmq_admin2022-05-11T15:15:58+01:00May 11th, 2022|News|

Neuronet (Efficiently Networking European Neurodegeneration Research, https://www.imi-neuronet.org/) just launched a new version of their Decision Tool to support engagement with Regulatory and Health Technology Assessment (HTA) bodies. The Decision Tool provides a clickable overview of the processes and procedures for HTA and regulatory interactions at different stages of the development pipeline to help ensure that the outputs being developed by Innovative Medicines Initiative research projects are relevant for regulatory and HTA settings, where applicable. Neuronet, a Coordination and Support Action [...]