Publication news from DZNE
Our PI Prof. Donato A. DiMonte of the German Center for Neurodegenerative Diseases (DZNE) and co-authors Michael Helwig, Ayse Ulusoy, Angela Rollar, Sinead A. O’Sullivan, Shirley S. L. Lee, Helia Aboutalebi, Rita Pinto-Costa, Benjamin Jevans, and Michael Klinkenberg announce the publication of "Neuronal hyperactivity–induced oxidant stress promotes in vivo alpha-synuclein brain spreading" in Volume 8, No. 35 of Science Advances on August 31st, 2022. DOI: 10.1126/sciadv.abn0356
Check out our final newsletter!
It's hard to believe we reached the end of the project in July 2022. Our final newsletter is now out, with an update on our most recent publications and dissemination activities. You can also read about our last consortium meeting in Copenhagen, including the parting thoughts of our public patient involvement (PPI) volunteers.
Review article from DZNE published in The Lancet
"AIFM1 beyond cell death: An overview of this OXPHOSinducing factor in mitochondrial diseases," an open-access review article prepared by Lena Wischhof, Enzo Scifo, Dan Ehninger and our PD-MitoQUANT PI Daniele Bano was published in eBioMedicine, part of The Lancet Discovery Science on August 18th, 2022. The research team is based at the German Center for Neurodegenerative Diseases (DZNE), in Bonn, Germany. DOI: https://doi.org/10.1016/j.ebiom.2022.104231 Summary: Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology. In this regard, a large number of studies have elucidated AIF’s participation to chromatin condensation during cell death in development, cancer, cardiovascular and brain disorders. However, the discovery of rare AIFM1 mutations in patients has shifted the interest of biomedical researchers towards AIF’s contribution to pathogenic mechanisms underlying inherited AIFM1-linked metabolic diseases. The functional characterization of AIF binding partners has rapidly advanced our understanding of AIF biology within the mitochondria and beyond [...]
New PD-MitoQUANT research published in IEEE conference proceedings
Congratulations to PD-MitoQUANT researchers Prof. Jochen Prehn, Dr Niamh Connolly and Sandeep Chenna of the RCSI! Their paper "Phenomenological equations for electron transport chain-mediated reactive oxygen species metabolism" was published open access on July 8th, 2022 as part of the 2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) proceedings. DOI: 10.1109/BIBM52615.2021.9669351 Download the PDF here.
Parting Thoughts from our Public Patient Involvement Volunteers
We’ve been privileged to have two people with Parkinson’s join the consortium. At our final project meeting in Copenhagen, Richard and Paula gave an inspirational farewell message, highlighting why continuing Parkinson’s research is so important. You can see their final presentation here. Richard Campbell I was very impressed by the co-operation of the different research laboratories, academic institutions, pharmaceutical companies and charities in the PD-MitoQUANT consortium. The leadership and management of the project was of a very high level. Such a wide ranging and substantial effort is needed if we are to find a cure for Parkinson’s or at least have a chance of slowing the progress of the disease or improving treatments in future. This philosophy of the consortium must continue even if the present grant ends in July 2022. Such research into the basic causes of Parkinson’s is needed to support [...]