PD-MitoQUANT is one of twelve research projects launched by the Innovative Medicines Initiative, Europe's biggest public and private collaboration in life sciences, which aim to better understand and develop treatments for neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. PD-MitoQUANT has joined forces with these research projects on the Neuronet platform to aid progress and expedite the delivery of novel treatments. A memorandum of understanding was jointly signed by Coordinator Prof Jochen Prehn, RCSI and Carlos Díaz, Coordinator of Neuronet on October 9, 2019. Neuronet aims to help scientists identify gaps in research, make findings more visible for society as a whole and create links between Innovative Medicines Initiative projects and other international research initiatives. Learn more about the Neuronet project here: https://www.imi-neuronet.org/
In October 2020, PD-MitoQUANT PI Dr Ronald Melki, CNRS is co-chairing the Jacques Monod conference which is themed: Protein phase transitions in ageing and age-related diseases: from atomic resolution to cellular solutions. Several PD-MitoQUANT PIs will present here. Where: Roscoff (Bretagne), France When: October 12-16, 2020 REGISTRATION REQUEST and ABSTRACT SUBMISSION DEADLINE: June 12, 2020 The conference- Cells and organisms maintain protein homeostasis in several cooperating ways, which include protein folding, degradation, and sequestration. During aging, the capacity to maintain protein homeostasis declines, which leads to the accumulation of aggregation-prone proteins. These aggregation-prone proteins can accelerate aging and cause age-related diseases like Parkinson’s disease, tauopathies, Alzheimer’s, and Amyotrophic Lateral Sclerosis. How they do so is still not fully understood. Understanding the underlying mechanisms will be important for the development of therapeutic strategies. Recent groundbreaking discoveries have revealed new aspects of protein homeostatic and pathological mechanisms. These include the phenomena of protein [...]
PD-MitoQUANT PI Dr Ronald Melki of the Centre National de la Recherche Scientifique, CNRS was an invited speaker at the International Symposium on Neurodegenerative Diseases organized by the University of Texas Southwestern O’Donnell Brain Institute in Dallas, Texas and the Texas Alzheimer’s Research and Care Consortium. The meeting took place on October 24 and 25, 2019 at the T. Boone Pickens Biomedical Building, NG3.11. Ronald's talk entitled "Prion-like propagation of alpha-synuclein and Tau assemblies in synucleinopathies and tauopathies" was facilitated on October 25th. The symposium highlighted the latest advances in clinical, translational, and basic research on Alzheimer’s disease and related disorders, and featured prominent national and international speakers.
Institut du Cerveau et de la Moelle Epinière (ICM) PI Dr Olga Corti presented her work and acknowledged PD-MitoQUANT at two recent conferences. The first conference presentation was on September 3, 2019, at the 23rd Biennial ESN meeting in Milan. Olga's talk was titled: “From dysfunction of PINK1/Parkin-mediated mitochondrial quality control to Parkinson’s disease”. See the entire programme here. In Coimbra, Olga presented at the 8th Workshop of the European Calcium Society. Her presentation was “Mechanisms underlying regulation of mitochondrial quality by the PINK1/Parkin pathway and consequence of their dysfunction” was delivered on September 19, 2019.
PD-MitoQUANT partners at Institut du Cerveau et de la Moelle Epinière recently co-authored a study entitled "The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells." in Scientific Reports on August 14, 2019. This work was undertaken by M. Jacoupy, E. Hamon-Keromen, A.Ordureau, Z. Erpapazoglou, F. Coge, J.-C. Corvol, O. Nosjean, C. Mannoury laCour, M. J. Millan, J.A. Boutin, J.W. Harper, A. Brice, D.Guedin, C.A.Gautier and O. Corti. Congratulations to the team! "Most of over a thousand mitochondrial proteins are encoded by nuclear genes and must be imported from the cytosol. Little is known about the cytosolic events regulating mitochondrial protein import, partly due to the lack of appropriate tools for its assessment in living cells. We engineered an inducible biosensor for monitoring the main presequence-mediated import pathway with a quantitative, luminescence-based readout. This tool was used to explore the regulation of mitochondrial import by the [...]