The German Center for Neurodegenerative Diseases (DZNE) is an interdisciplinary research centre, established in 2009 by the Federal Ministry of Education and Research (BMBF) to consolidate and expand scientific resources on neurodegenerative diseases and to foster the translation of scientific findings into medical applications. The focus is on Alzheimer’s disease and other dementias, Parkinson’s disease and more rare conditions such as ataxia, amyotrophic lateral sclerosis and prion diseases. The general research strategy is to bridge expertise in four scientific areas: Fundamental Research, Clinical Research, Population Health Sciences and Health Care Research. Highly interactive work is carried out by > 80 research groups at ten DZNE sites across Germany. Collaborative work also involves interactions between the DZNE and universities, university hospitals and other research and clinical partners.
DZNE will contribute expertise in in vivo models:
- harmonising in vivo models of αSyn pathology,
- investigating mitochondrial bioenergetics in vivo,
- examining mitochondrial structure and αSyn interactions ex vivo, and
- interrogating key drivers and validating master regulators in invertebrates