GeneXplain GmbH (geneXplain) is a leading software company providing systems biology platform for deciphering mechanisms of biological processes and human diseases. GeneXplain was founded by the originator of the TRANSFAC database, Prof. Dr. Edgar Wingender and by the creator of promoter and network analysis algorithms, Dr. Alexander Kel. TRANSFAC. is a unique database on eukaryotic transcription factors (TF), their genomic binding sites and DNA-binding profiles (PWMs).
GeneXplain will identify significant transcriptome/proteome changes associated with αSyn toxicity and mitochondrial dysfunction and identify master regulators and dominant signalling pathways of cellular toxicity and mitochondrial dysfunction associated with αSyn.