The Institut du Cerveau – Paris Brain Institute (ICM) is a non-profit research foundation created in 2010, collaborating with public partners (Sorbonne Université, CNRS, INSERM and AP-HP). The 25 research teams, and state of the art technology facilities carry top-level international research on the normal brain function, and diseases of the nervous system. The ambition of the ICM is to break new grounds in basic neuroscience, and in the diagnosis and care of nervous system diseases.
ICM are scientific co-leaders, and will lead the in vivo research work package, including:
- harmonising in vivo models of αSyn pathology,
- investigating mitochondrial bioenergetics and dynamics in vivo, and
- interrogating key drivers and validating master regulators in invertebrates
The ICM team will also play a key role in the in vitro research:
- establishing in vitro models and looking at mitochondrial dynamics, mitophagy and protein import resulting from exposure to αSyn fibrils, and
- identifying dysregulated mRNA/proteins for validation in 3D in vitro