Project Description

Institut du Cerveau – Paris Brain Institute (ICM)

The Institut du Cerveau – Paris Brain Institute (ICM) is a non-profit research foundation created in 2010, collaborating with public partners (Sorbonne Université, CNRS, INSERM and AP-HP). The 25 research teams, and state of the art technology facilities carry top-level international research on the normal brain function, and diseases of the nervous system. The ambition of the ICM is to break new grounds in basic neuroscience, and in the diagnosis and care of nervous system diseases.

ICM are scientific co-leaders, and will lead the in vivo research work package, including:

  • harmonising in vivo models of αSyn pathology,
  • investigating mitochondrial bioenergetics and dynamics in vivo, and
  • interrogating key drivers and validating master regulators in invertebrates

The ICM team will also play a key role in the in vitro research:

  • establishing in vitro models and looking at mitochondrial dynamics, mitophagy and protein import resulting from exposure to αSyn fibrils, and
  • identifying dysregulated mRNA/proteins for validation in 3D in vitro
ICM logo
Olga Corti
Olga Corti
PD-MitoQUANT Scientific Co-Leader,
Investigation of mitochondrial dysfunction in alpha-synuclein-based models
Philippe Ravassard
Philippe Ravassard
Induced pluripotent stem cell technology and transcriptome profiling
Stéphane Hunot
Stéphane Hunot
Modeling of alpha-synuclein-dependent pathology and mitochondrial dysfunction in mice
Patrick Michel
Patrick Michel
Disease modeling in primary neurons and neuron-glia co-cultures
Bassem Hassan
Bassem Hassan
Modifiers of alpha-synuclein-dependent toxicity and mitochondrial dysfunction in Drosophila melanogaster
Aurore Tourville
Aurore Tourville
α-synuclein fibrils in primary mesencephalic neurons
MSc, research engineer
Sidi Mohamed Hassoun
Sidi Mohamed Hassoun
Mitochondrial bioenergetics in cellular and in vivo models of α-synucleinopathy
PhD, research engineer
Noemi Asfogo
Noemi Asfogo
Mitochondrial and cell functions in primary mouse and human iPSc-derived neurons
PhD student
Patricia Lino
Patricia Lino
Mitochondrial bioenergetics in human iPSC-derived neurons and mouse models
MSc, research engineer
Nicola Grillenzoni
Nicola Grillenzoni
PhD, research engineer
Maeva Vallucci
Maeva Vallucci
α-synuclein fibril-induced pathology in mice
MSc, Research Engineer