The RCSI (Royal College of Surgeons Ireland) is an international health sciences institution focused on driving improvements in human health worldwide. RCSI is ranked among the top 250 (top 2%) of universities worldwide in the Times Higher Education World University Rankings (2019). With a field-weighted citation index of 1.97, its research ranks 1st in Ireland and double the global average for citations of similar publications (SciVal, 2013-2017).
RCSI is coordinating PD-MitoQUANT and leading the in vitro research work package, including:
- experimentally evaluating fibrils for apoptosis and necrosis (cell death) in in vitro models,
- measuring mitochondrial bioenergetics, dynamics, morphology and stress response in in vitro models,
- conducting network analyses of integrated transcriptomic and proteomic data using bioinformatics and systems modelling approaches,
- determining key drivers and combinatorial signatures of mitochondrial dysfunction, and designing measurable endpoints for translation of signatures to other in vitro and in vivo models.
The RCSI team will also play a key role in the in vivo research, designing endpoint assays and an experimental platform for the investigation of mitochondrial function.